【摘要】 用丙二酸酯法合成了Ｎ－乙酰基－３－（２－萘基）－ＤＬ－α－丙氨酸乙酯３．３经酶法拆分，得光学活性的Ｄ－３，后者经盐酸水解、酯化后再与苯基溴化镁作用，制得标题化合物６。在０．５ｍｍｏｌ６存在下，用过量硼烷对一系列前手性酮还原，得到了相应的光学活性二级醇。对映体过量（ｅ．ｅ值）５７．０～１００％。更多还原

【Abstract】 N-Acetyl-3-(2-naphthyl )-DL-α-alanine ethyl ester DL-3 was prepared via malonic ester method. The resolution of DL-3 with subtilisin earlsberg afforded D-3 , which, after converted to the corresponding amino acid methyl ester hydrochloride, reacted with phenyl magnesium bromide giving the title compound 6.In the presence of 6( 0.05 equiv.),prochiral ketones were reduced with excess borane yielding optically active secondary alcohols with e.e.57.6～100%.更多还原