【摘要】 本文研究了通过胎盘和乳汁暴露铅对小鼠仔代活动性行为及中枢多巴胺水平的影响。结果表明，仔鼠血及脑中铅含量明显增加，其血铅含量与母体血铅呈正相关；低浓度铅（血铅值为１．２５μｍｏｌ／Ｌ）并不影响仔鼠大脑中多巴胺的水平，但却增加了仔鼠的站立行为；高浓度铅（血铅值为３．９４μｍｏｌ／Ｌ）不仅增加了仔鼠的活动性行为，还进一步导致中枢多巴胺水平的变化。提示：铅对行为的影响较为敏感。当多巴胺水平尚未见显著变化时，可发生行为的改变。更多还原

【Abstract】 The effects of lead exposure through the placenta and milk of lead-treated mother mice on activity and brain dopamine (DA) level in their offsprings were studied. Blood and brain lead concentration were increased in newborn mice and there is a positive association between mother’s and pup’s blood lead concentration. In newborn mice, the change of endogeneous DA level was not seen on blood lead level of 1. 25Pμmol/L, but the rearing response behavior was enhanced. Larger doses of lead (blood level 3. 94μmol/L)significantly increased the level of brain DA and showed hyperactivity. These evidences suggest that the effect of lead on behavior is more sensitive. Subtle neurochemical changes would result in severe behavior alterrations.更多还原