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鲎试验法检测甲硝唑注射液热原的研究
Detection of Pyrogen in Metronidazole Injection by Limulus Test
【摘要】 本文探讨了鲎试验法用于检测甲硝唑注射液中热原的可行性。通过检品对鲎试验的干扰验证和鲎实验法与家兔法的对比,结果认为,检品对鲨试验无干扰,该法可代替家兔热原试验,使90%以上的甲硝唑注射液检品不再进行繁琐而费时的家兔热原检查。
【Abstract】 The possibility of using limulus tests to detect pyrogen in metronidazole injectionwas investigated by interfering-test and compared with the rabbit pyrogenic test. The resultssuggest that the limulus test is not interfered by the test samples, and could substitute for the rab-bit pyrogen test. This will make it possible for more than 90% of metronidazole injection samplesnot need to be detected with the complex and time-consuming rabbit pyrogenic test.
- 【文献出处】 广东药学院学报 ,ACADEMIC JOURNAL OF GUANGDONG COLLEGE OF PHARMACY , 编辑部邮箱 ,1996年02期
- 【分类号】R927.12
- 【被引频次】2
- 【下载频次】18