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富勒醇清除·OH自由基的ESR研究
An ESR Study on OH-radical Scavenging Activity of Water-soluble Fullerenols
【摘要】 富勒醇清除·OH自由基的ESR研究祝严师,孙大勇,刘桂珍,刘子阳,詹瑞云,刘淑莹(中国科学院长春应用化学研究所应用谱学开放实验室,长春,130022)关键词C60,富勒醇,OH自由基,自旋捕捉,ESR生物体内的许多现象均涉及到自由基反应,现已发?..
【Abstract】 Water-soluble polyhydroxylated fullerene derivatives(fullerenol) were synthesized,and their scavenging ability for OH-radical was studied by the combination of ESR spectroscopy and spin-trapping technique with phenyl-t-butyl-nitrone. It was found that fullerenols showed an excellent efficiency in eliminating OH free radicals generated by UV photolysis of H2O2.At an applied fullerenol concentration of 0.3mg/mL in the final solution,a radical scavenging efficiency of approximate 95%was achieved, revealing the potential use of these compounds as novel potent free radical scavengers in biological systems.
- 【文献出处】 高等学校化学学报 ,CHEMICAL RESEARCH IN CHINESE UNIVERSITIES , 编辑部邮箱 ,1996年07期
- 【分类号】O621.1
- 【被引频次】21
- 【下载频次】249