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聚苯乙烯-g-聚氧乙烯接枝共聚物表面阻抗蛋白质吸附的研究
Studies on Protein-Resistance of AmphiphilicPolystyrene-g-Poly (ethylene oxide)Copolymers
【摘要】 利用放射性碘标记技术研究了血浆蛋白质-缓冲溶液体系在聚苯乙烯-g-聚氧乙烯接枝共聚物表面的等温吸附和吸附动力学。材料表面蛋白质等温吸附量或平衡吸附量随表面PEO含量增加而下降;吸附量最低值小于0.25μg,cm-2;同时探讨了材料表面“梳状”结构对材料表面PEO侧链阻抗蛋白质性能的影响。
【Abstract】 The adsorption isotherm and kinetics of simple plasma protein (human serum albumin immunoglobulin or fibrinogen)-buffer onto the surfaces of (PS-g-PEO) graft copolymers were investigated by radioiodine labelling technique.The reliability of IC1 labellingmethod was verified. It was discovered that the plateau protein adsorption amount usuallydecreased with surface PEO content of PS-g-PEOs increasing;the lowest protein plateau adsorption values were observed <0. 25 μg. cm-2.The "comb-like" structure of model materials might be more fit for protein-resistant property of PEO side chains.
【Key words】 Surface structure of polystyrene-g-poly (ethylene oxide); Protein-resistance; Isothermal adsorption of plasma proteins;
- 【文献出处】 高等学校化学学报 ,CHEMICAL RESEARCH IN CHINESE UNIVERSITIES , 编辑部邮箱 ,1996年04期
- 【分类号】R318.08
- 【被引频次】12
- 【下载频次】155