【摘要】 转移生长因子ＴＧＦβ３是一种多功能调节剂，不同的给药剂量、给药次数及其间隔时间以及给药后的测定时间等均影响它对细胞增殖调控的能力。当重复给予ＴＧＦβ３，它对正常小鼠及８Ｇｙγ射线全身照射小鼠小肠隐窝底部的上皮细胞的增殖均起抑制作用，且随着给药次数的增多，ＴＧＦβ３对肠隐窝干细胞的抑制作用逐渐增强，提示它是干细胞生长的负调节因子。更多还原

【Abstract】 Transforming growth factor 6 3 (TGFβ 3) is a multifunctionalregulator of cell growth. In epithelial tissue TGFβ 3 was found to be a negativeregulator of growth, it inhibits the proliferation in the small intestinal crypts ofthe mouse following in vivo administration. Various doses and dosing regimenswere tested, TGF β 3 was an effective inhibitor of proliferation in unirradiated andafter irradiated 18 hours recipients in all multiple doses cases, TGF6 3 tended tohave its strongest inhibitory effects in the lower regions of the crypt.更多还原