节点文献

大剂量X射线照射对雄性大鼠某些组织LPO水平及CuZn-SOD和Se-GSH-Px活性的影响

EFFECT OF HIGH DOSE IRRADIATION ON LPO LEVELS AND CuZn SOD AND Se GSH Px ACTIVITIES OF SOME TISSUES IN MALE RATS

  • 推荐 CAJ下载
  • PDF下载
  • 不支持迅雷等下载工具,请取消加速工具后下载。

【作者】 孙铁华龚守良张铭刘树铮

【Author】 Sun Tiehua Gong Shouliang Zhang Ming Liu Shuzheng(Norman Bethune University of Medical Sciences, Changchun, 130021)

【机构】 白求恩医科大学

【摘要】 本研究观察大剂量X射线照射雄性大鼠72h后免疫和内分泌等组织脂质过氧化物(LPO)水平及超氧化物歧化酶(CuZn-SOD)和谷胱甘肽过氧化物酶(Se-GSH-Px)活性的变化。结果发现,胸腺、脾脏、肾上腺和肝脏LPO水平随照射剂量的增加而增高;脾脏和肝脏CuZn-SOD活性在4Gy以上剂量照射后即升高,但在10Gy照后增高明显;胸腺和脾脏Se-GSH-Px活性在4Gy以上剂量照射后即明显高于对照组,睾丸Se-GSH-Px活性也有增高趋势,其中10Gy组增高明显;但是,4Gy以上剂量照射后胸腺CuZn-SOD和肾上腺Se-GSH-Px活性降低

【Abstract】 The present study was designed to observe lipoid peroxide (LPO) levels and CuZn superoxide dismutase (CuZn SOD) and Se glutathione peroxidase (Se GSH Px) activities of immune and endocrine tissues in male rats after X irradiation at 4-10 Gy. LPO levels in thymus, spleen, adrenal and liver increased with increase of doses. Spleen and liver CuZn SOD activities increased after irradiation at 4 Gy or more, and significantly in 8 Gy or 10 Gy groups. Thymus and spleen Se GSH Px activities after 4 Gy or more irradiation were significantly higher than that in 0 Gy group. Testis Se GSH Px activity also tends to increase after irradiation, and significantly in 10 Gy group. But, thymus CuZn SOD and adrenal gland Se GSH Px activities decreased after 4 Gy or more irradiation. The above mentioned results are further discussed. (

  • 【文献出处】 辐射防护 ,PADIATION PROTECTION , 编辑部邮箱 ,1996年06期
  • 【分类号】R144.1
  • 【被引频次】4
  • 【下载频次】46
节点文献中: 

本文链接的文献网络图示:

本文的引文网络