【摘要】 目的探讨肿瘤标志物联合检测在肝细胞癌诊断中的临床意义。方法应用酶联免疫吸附法（ＥＬＩＳＡ），参考Ｔｒｏｏｓｔ法和分光光度法分别对３０例肝细胞癌患者、３０例肝硬化患者及３０例正常人（对照组），进行血清甲胎蛋白（ＡＦＰ）、α－Ｌ－岩藻糖苷酶（ＡＦＵ）和唾液酸（ＳＡ）测定。结果肝癌患者上述各项肿瘤标志物水平均明显高于肝硬化组和对照组（Ｐ＜０．０１），肝癌患者血清中ＡＦＰ、ＡＦＵ和ＳＡ的阳性率分别为７０．０％，７６．２％和７０．０％。将上述３项肿瘤标志物进行联合检测，以任２项阳性为诊断标准，则联合检测对肝癌诊断的敏感性为８６．７％，特异性为９８．３％，准确性为９４．４％，阳性预示值为９３．７％，阴性预示值为９６．３％。结论血清ＡＦＰ、ＡＦＵ和ＳＡ联合检测对肝癌诊断具有实用价值。更多还原

【Abstract】 To explore the clinical significance of combined measurement of serum tumor markers for hepatocellular carcinoma diagnosis.Methods Serum alpha-fetoprotein(AFP),alpha-L-fucosidase(AFU)and sialic acid(SA) were measured by enzyme-linked immunosorbent assay(ELISA),Troost method and spectrophotometry respectively in 30 patients with hepatocellular carcinorna(HCC),30 patients with liver cirrhosis(LC)and 30 normal individuals.Results Taking each of three tumor markers(AFP,AFU and SA)as the diagnostic criterion of HCC,the positive rate was 70.0%,76.2%and 70.0%respectively.If any two positive results among three tumor markers were chosen as the diagnostic criteria of HCC,the sensitivity,specificity,positive predictive value,negative predictive value and accuracy for HCC patients were 86.7%,98.3%,93.7%,96.3%and 94.4%respectively.Conclusion It was suggested that the combined measurement of three tumor markers might be of practical significance for HCC diagnosis.更多还原