【摘要】 目的评价咖啡因清除试验作为定量肝功能试验的临床应用价值。方法口服２５０ｍｇ咖啡因后测定二次受试者血药浓度，计算咖啡因清除率。共检测２３例对照组及６０例各种肝病患者。结果对照组咖啡因清除率（ＣＬ）为１．６０±０．４ｍｌ／ｋｇ·ｍｉｎ－１，慢性肝炎、酒精性肝病患者的ＣＬ轻度降低，肝硬化组严重降低。肝硬化患者的ＣＬ与Ｃｈｉｌｄ评分呈明显负相关；ＣＬ极度降低者生存期短。以对照组ＣＬ的－１ｓ为临界值，则本试验对肝功能异常的敏感度为８８．３３％，特异度为８６．９６％，准确度为９１．２５％。结论咖啡因清除试验是一个方便、可靠的肝脏贮备功能指标。更多还原

【Abstract】 Objective Research of the clinical value of caffeine clearance test.Methods Caffeine cleasance(CL) quantitative index of liver diseases had been evaluated in 23 normal controls and 60 patients with various liver diseases,Results Compared to normal value in controls (1. 60±0.48 ml/kg·min-1),CL was significantly reduced in patients with chronic hepatitis and in patients with alcoholic liver disease,the patients of cirrhosis even more markedly.There was a significant correlation between CL and Child-Pugh classification score(r=-0.70,P<0.01).If the mean of control values minus is(1.12 ml/kg· min-1)was usedas a cut point,the sensitivity,specificity,accuracy rate,positive and negative predictive value for assessing of liver function impairment was 88. 33%, 86. 96%, 91. 25%, 94. 64% and 74. 07%,respectively. Conclusion The caffeine clearance test is suitable for routine assessment of liver reserved function.更多还原