【摘要】 本文介绍1989年～1993年在国内首次采用Spot点片法对辽宁地区正常儿童进行神经母细胞瘤(Neuroblastoma,NB)的早期筛查。在50350例正常儿童中,筛查出无临床症状的可疑病人4例。其spot点片法均为阳性,层析结果分别出现香草扁挑酸(VMA),高香草酸(HVA),香草乳酸(VLA);VMA定量超过正常值。经B超、磁共振(MRI)检查,3例均在左肾上腺发现肿物(3.5cm×2.0cm,2.0cm×2.0cm,2.0cm×2.5cm)诊断为NB.1例接受手术治疗。2例放射治疗,目前均健康生存。另1例经B超、磁共振多部位探查,未发现肿物,列为追踪观察对象。初得辽宁地区小儿NB发病率约为6/10万。更多还原

【Abstract】 Early screening of neuroblastoma (NB) in 50 350 normal children was down first by using urine spot test and two-dimensional paper chromatography in Liaoning province of China. Four NB patients without any clinical sign were found. The result showed that urine spot test from these patients were positive,vanillylmandelic acid (VMA), homovanillic acid(HVA),3-methoxy-4-hydroxyphenyllactic acid (VLA)were appeared respectively on chromatogram ,and VMA quantity was over normal level. Tumor of left renicapsule was found in 3 cases of them by ultrasonoscope and MRI,the other one need be followed further. The incidence rate of NB is 6 in 10 5 in Liaoning province.更多还原