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新型硬化剂的动物实验与临床应用

NEW SCLEROSING AGENT:THE RESULT OF ANIMAL EXPERIMENT AND CLINICAL USE

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【作者】 张涛; 田庚善; 蔺小红; 那加; 赵鸿; 万华;

【Author】 ZHANG Tao;TIAN Gengshan ;LIN Xiaohong ;NAJia ;ZHAO Hong;WAN Hua(Department of Infection;First Hospital, Beijing Medical University 100034)

【机构】 北京医科大学第一医院感染疾病科;

【摘要】 目的:寻找更有效的硬化剂治疗食管静脉曲张破裂出血。方法:配制一种新型硬化剂,其成分为1.5%孟氏液70ml、20%利多卡因20ml、红霉素0.5g及注射用水10ml,将这种硬化剂注射到兔耳的血管内,还应用于9例肝硬化食管静脉曲张破裂出血病人,并设对照组。结果:新型硬化剂局部止血比5%鱼肝油酸钠和消痔灵的效果好,临床止血效果与1%乙氧硬化醇相同,且对动物肝、肾无损害。结论:新型硬化剂具有安全、有效、副作用小而价廉的优点。

【Abstract】 Objective:More effective agent to treat the patients with looking for esophageal variceal bleeding. Methods:We made a new sclerosing agent consisting of 15%Monsel′s solution 70 ml,20% lidocaine 20 ml,erythromycin 0.5 g and water 10 ml.In animal experiment,We used it as a sclerosing agent and injected it into the blood vessels of the ear of the rahhits.The new sclerosing agent was also used in 9 patients suffering from bleeding of varicosis of liver cirrhosis. Results: We found that the new sclerosing agent had a better effect on local blood coagulation than that of 5% sodium morrhuate or Xi-aozhiling,It had no harmful effect on liver and kidney functions Also,it doesn′t influence the PTA.The effect of blood coagulation is the same as that of 1% aethoxyscklerol.However,it is much cheaper with only one percent of the latter′s price.Conclusion:The new sclerosing agent is a safe effective and cheape agent,with few side effects.

  • 【文献出处】 北京医科大学学报 ,JOURNAL OF BEIJING MEDICAL UNIVERSITY , 编辑部邮箱 ,1996年05期
  • 【分类号】R571.305
  • 【被引频次】1
  • 【下载频次】49
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