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枸杞多糖对小鼠胸腺细胞凋亡的调节

THE REGULATION OF LYCIUM BARBARUM POLYSACCHARIDE ON APOPTOSIS OF MOUSE THYMOCYTE IN VITRO

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【作者】 刘玉涛周禾白小薇殷金珠

【Author】 LIUYutao;ZNOUHe;BAIXiaowei ;YLNJinzhu(Department of Immunology. Beijing McdicalUniveraity 100083)

【机构】 北京医科大学免疫学系

【摘要】 目的:以DEX诱导小鼠胸腺细胞凋亡为模型,研究中药枸杞多糖(LyciumBarbarumPolydsc-charide.LBP)及氧化苦参碱(OXY)对胸腺细胞凋亡的调节作用。方法:应用PI法检测亚2倍体细胞,二苯胺法测定胸腺细胞DNA片断化%及DNA凝胶电泳。结果:LBP可抑制DEX诱导的DNA片断化,其抑制作用具有剂量依赖性,以1g/L最明显;LBP(lg/L)尚可阻止DEX诱导的胸腺细胞内Ca ̄(2+)升高。结论:LBP可抑制DEX诱导的小鼠胸腺细胞凋亡,OXY对此无明显的调节作用。

【Abstract】 Objective. The apoptosisofmurine thymocytes induced by DEX was regulated by LBP and OXY. Methods. PI staining. DNA fragmentation. DNA gel electrophoresis.and so on Results.LBP could inhibit fragmentation of DNA in murine thymocyte induced by DEX.The inhibition is dose-depen-dent and obvious. especially in 1 g/L.Ithas been shown that LBP could greatly reduce the rising of in tracellular Ca2+concentrathn induced by DEX or A23187 respectively.(%of inhibition .54 and 13).Conelusion. LBPcould inhibit the apoptosis induced by DEX.which OXY doesn’t have any effect on.

【基金】 中华洛氏基金
  • 【文献出处】 北京医科大学学报 ,JOURNAL OF BEIJING MEDICAL UNIVERSITY , 编辑部邮箱 ,1996年02期
  • 【分类号】R285.5
  • 【被引频次】91
  • 【下载频次】221
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