【摘要】 目的：预防骨髓移植后发生移植物抗宿主病和排斥反应。方法：紫外线Ｂ体内照射、紫外线Ｂ照射的供（受）者特异输血及环孢菌素Ａ结合的方式、在供者（Ｃ５７ＢＬ／６）、受者（Ｂａｌｂ／ｃ）小鼠间行双向诱导免疫耐受，再进行骨髓移植。结果：１只小鼠在移植后第３０ｄ死于移植物抗宿主病，９／１０的小鼠存活＞２００ｄ。而混合移植（Ｂａｌｂ／ｃ＋Ｃ５７ＢＬ／ｃ→Ｂａｌｂ／ｃ，１：４）组，１０／１０的小鼠存活＞２００ｄ。结论：双向诱导免疫耐受预防小鼠骨髓移植后发生移植物抗宿主病和排斥反应是必要的。更多还原

【Abstract】 Ohjectlve . in order to avoid both graft versus hoxt desease(GVHD(and rejection in hone niarrow transplantation(BMT).Methods. Ultraviolet B irradiation. ultraviolet B irradiated donor spe-cific transfusion (UV-DST. UV-RST)and CsA treatment were used in this study to induce antigen spe-cific tolerance between donor and recipient mice before BMT. kesults. 1 died on 30th day due to GVHD. while 9 survived >200 days without any evidence of GVHD. All of 10 mice who received mixed BMT(Balb/c+C57BL/6-Balb/c.1: 4) had lived > 200 davs. Conclusion . Two sides induction of speciflc immunotolerance between donorand recipient was necessary to prevent both GVHD and rejec-tinn for murine BMT.更多还原