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99mTc标单抗在荷人卵巢癌裸鼠体内T/N比值的观察

T/N RATIO OBSERVATION OF ̄(99m)TC LABELLING McAB IN NUDE MICE BEARING OVARIAN SEROUS ADENOCARCINOMA

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【作者】 林文玉钱和年冯捷李文锦高伯山岳明纲万里明高书明

【Author】 LIN Wenyu;QIAN Henian; FENGJie; LIWenjin; GAO Boshan; YUE Minggang; etal(CynecologicOncology Research Laboratory. People’s Hoxpital. Beijing Medical University 100044)

【机构】 北京医科大学人民医院妇科肿瘤室

【摘要】 目的:找出在注射标记抗体的荷瘤裸鼠体内的 ̄(99m)Tc注射剂量、时间与T/N比值的关系。方法:用γ计算机和γ计数器测定肿瘤和其它组织的放射性强度,计算T/N比值和定位指数LI.结果:(1)2mci的 ̄(99m)Tc剂量T/N比值高;(2)注射标记抗体28h后,T/N比值高,是放免显象的适宜6时间。结论: ̄(99m)Tc剂量大小与T/N比值不呈线性关系,但T/N比值与定位指数呈正相关。

【Abstract】 Ohjective. To find out the relation of99m Tc Injection dosages and times to high T/Nratios in the nude mice models injected with the lahelled antibody. Methods. The radioactivities of tumors and other organs(tissues)were measured by gama cornputer and gama counter. T/V ratlo and LIwere cal-culated. Results:(1) 2 mCi dosages was suitable for high T/N. (2) After 28 hours of injection T/Nra-tios were appropriate for RII.Conculsion. Between 99mTc dosages and T/N ratioa there was no linear relation. But T/N and LIshowed positive interrelation.

【基金】 卫生部基金
  • 【文献出处】 北京医科大学学报 ,JOURNAL OF BEIJING MEDICAL UNIVERSITY , 编辑部邮箱 ,1996年02期
  • 【分类号】R737.31
  • 【被引频次】3
  • 【下载频次】30
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