【摘要】 目的：了解笑气与其它麻醉药合用时所产生的麻醉强度。方法：５６例择期手术病人，随机分成８组，各组病人分别应用不同浓度的笑气（Ｎ＿２Ｏ）和异氟醚（ＩＳＯ），保证每组病人的呼气末麻醉药浓度达到１．０ＭＡＣ，脑电功率谱及９５％边缘频率（ＳｐｅｃｔｒａｌＥｄｇｅＦｒｅｑｕｅｎｃｙ，ＳＥＦ）。结果：应用７０％Ｎ＿２Ｏ组病人的ＳＥＦ值最大，单纯ＩＳＯ组的ＳＥＦ值最小（Ｐ＜０．０５）。结论：７０％、６０％、５０％、４０％的麻醉效能达不到０．７、０．６、０．５、０．４ＭＡＣＩＳＯ的麻醉强度，临床麻醉中应适当增加其它麻醉药的用量。更多还原

【Abstract】 Objective:The purpose of this study was to observe the anesthesia effect of different concen-trations of nitrous oxide（N₂O）when it was used with other inhaling anesthetics such as isoflurane.Methods Fifty-six patients,scheduled for elective surgery,were divided randomly into eight groups.From group Ⅰ to Ⅷ,patients were anesthesiaed by 70%,60/,50%,40%,30%,20%,10%and 0%N₂O with 0.3,0.4,0.5,0.6,0.7,0.8,0.9 and 1.0 MAC isoflrurane respectively,so that all of the patients’additive MAC value was 1.0 MAC. When the additive MAC was maintained at 1.0 MAC for 15～20 minutes,spectral edge frequency （SEF） was recorded for five minutes after incision.Results:The pa-tients were anesthesiaed with 70% N₂O had biggest SFF value,while patients with isoflurane only had smallest SEF value.Conclusions:These data might suggest that 70% or 60%N₂O could not match what effect of 0.7 or 0. 6 MAC other inhaling anesthesics be.更多还原