【摘要】 目的：研究大剂量顺铂（ＤＤＰ）化疗的肾毒性及监测方法。方法：对１３例骨肉瘤术后病人，按每平方米体表面积１００ｍｇＤＤＰ静脉大剂量化疗。化疗前及化疗后９６ｈ分别测定血清尿素（ＵＲＥＡ）、血清肌酐（Ｃｒ）、血和尿中β＿２－微球蛋白（β＿２－Ｍ）的含量。结果：化疗后有１０例病人尿中β＿２－Ｍ含量升高（Ｐ＜０．０５）。结论：根据尿中β＿２－Ｍ值来观察接受大剂量顺铂化疗的骨肉瘤病人肾小管的损害程度，结果稳定可靠。化疗前尿中β＿２－Ｍ超过０．２５ｕｇ／Ｌ以上者要停止大剂量顺铂的化疗。更多还原

【Abstract】 Ohjective:Reseach into the renal damage of high-dose Cisplatin（9DP）chemotherapy and method of surveillance,Metbods 13 cases of postoperative osteosarcoma patients treated with Cisplatin（DDP）infusion were studied to determine whether urinary β₂-Microglobulin（β₂-M）is a reliable indica-tor to predict impaired excretion of Cisplatin. Before and after DDP infusions,the levels of urinary β₂-M were measured along with UREA,Cr and blood β₂-M.Results:After DDP inhsions,urinary β₂-M levels of 10 cases were elevated（P<0.05）.Conclusions:Urinary β₂-M is a sensitive indicator of reabsorption of renal tubules,and especially when levels of more than 0.25ug/L of urinary β₂-M are fund to exist,it seems difficult to clear the drug following Cisplatin treatment.更多还原