【摘要】 目的：研究新的神经递质ＮＯ在脊髓血压调节中枢的作用机理。方法：用ＮＤＰ组化方法观察ＮＯＳ在脊髓ＩＭＬ的分布。结果：ＮＯＳ细胞分布正常（ＷＫＹ）和自发性高血压大鼠（ＳＨＲ）脊髓ＩＭＬ全长。ＳＨＲ在Ｃ＿８～Ｔ＿４节段，ＮＯＳ细胞多于ＷＫＹ；在中胸以下节段ＮＯＳ细胞分布少于ＷＫＹ，均有显著性差异。结论：ＮＯ局部作用可能调节交感神经的兴奋性。ＳＨＲ交感神经紧张性增高，可能与中胸以下ＮＯＳ减少有关；ＮＯＳ在Ｃ＿８～Ｔ＿４节段增加可能与心脏向心性肥厚的代偿性活动有关。更多还原

【Abstract】 Ohjective:To study nitric oxide（NO）as a new transmitter which has active functions in the cardiovascular control center of IML.Methods:To observe the distribution of nitric oxide syntyase（NOS）-positlve cells by using NADPH diaphorase（NDP）-histochemistry staining.Results:The data showed that NOS-positive cells were distributedin in whole longitudinal IML both of the SHR and WKY,NOS-positive cells of SHR were more than WKY in the upper thoracic spinal segments （C₈～T₄）;NOS-positive cells of SHR were less than WKY from the middle thoracic to upper lumbar spinal segments,Analytic studies were carried out both on SHR and WKY.There were significant differences in SHR and WKY.the effect of the localized NO it is possible that IML maConclusions:Under y regu-late the activities of sympathetic nerves.An increaxein the activeties of sympathetic nerves of SHR may be involved by NOS-neurons declining in T₅～L₃.More NOS-neuron,in C₈～T₄ may result from compensation of hypertensive concentric hypertrophy更多还原