【摘要】 细胞形态学和白血病细胞系ＨＬ６０的实验研究表明，三氧化二砷（ＡＳ_２Ｏ_３）对急性早幼粒细白血病（ＡＰＬ）细胞有诱导分化作用；并可能是通过“原浆毒”作用同时诱导细胞凋亡；大剂量时有抑制细胞增殖作用，这三种作用的依次出现与治疗的累积量有关。认为砷剂是目前治疗ＡＰＬ的较理想药物。更多还原

【Abstract】 In this study,the data from cytomorpbological and experimental study on HL60cell line showed that cell differentiation and apoptotic cell death of acute promyelocytic leukemia(APL)cells can be induced by arsenic trioxide(713).Its inducing effects for apoptotic cell deathmay be made by protoplasmic poison type effect of arsenic.With large doses of “7l3”,cytopro-liferative suppression can be developed.These three different effects are related to the doses ofarsenic trioxide that we used.We conclude that arsenic trioxide injection is a ideal drug for treat-ment of APL.更多还原