【摘要】 本文对ＤＬ－聚乳酸－聚乙二醇共聚物（ＰＥＬＡ）体内外降解进行了研究。采用凝胶渗透色层法（ＧＰＣ）测定分子量，扫描电镜（ＳＥＭ）观察。ＰＥＬＡ在最初第５天出现降解，２月时分子量丧失体内外分别为９７．２８％和９２．０％，而重量仅丧失８％。对其原因进行了讨论，同时将ＰＥＬＡ与ＤＬ－聚乳酸（ＰＬＡ）进行了比较，探讨分析了二者的降解机理。结果表明ＰＥＬＡ是一种新型生物降解材料。更多还原

【Abstract】 The degradation of poly (DL-Lactic acid) and polyethyleneglycol block copolymer (PELA) was monitored in vitro and vivo. PELA degradation was observed in vivo at 5th day with scanning electron mioroscopy (SME), and molecular weight determined by gel permeation chromatography (GPC) showed a reduction to 97% after 8 weeks in vivo and 92% in vitro, whereas the mass loss change was 8% only. The causes were discussed, degradation of DL-PLA was studied in vitro and in vivo and was analyzed. The results showed that PELA is a new biodegradable copolymer.更多还原