【摘要】 为探讨联合化疗在鼻咽癌治疗中的作用，从１９９０年７月至１９９１年１２月把７６例经病理证实、初治的局部晚期（Ⅲ、Ⅳ期）鼻咽癌，随机分为联合化疗和放射治疗组（综合治疗组）以及单纯放疗组（对照组）各３８例。化疗方案：顺铂、氟脲嘧啶和平阳霉素。治疗３月后，综合治疗组和对照组鼻咽肿瘤完全消退率分别为８９．５％和９７．５％，颈转移灶完全消退率分别为９３．８％和９０．６％，两组均无显著性差异（Ｐ＞０．０５）。随访３年，综合治疗组和对照组３年生存率分别为６８．４％和６１．１％（ｘ２＝０．２８２）、无瘤生存率为６３．２％和４８．６％（ｘ２＝０．７３５）．无远处转移生存率为７０．７％和５６．１％（ｘ２＝１．３８２）．鼻咽肿瘤控制率为８４．７％和７７．５％（ｘ２＝０．３９４），颈转移灶控制率为８０．１％和８２．８％（ｘ２＝０．３８３），均无显著差异更多还原

【Abstract】 76 pa-tients with locally advanced nasopharyngeal carcinoma(NPC)(stage Ⅲor Ⅳ)were randomized to receive ei-ther combined chemotherapy and radiotherapy(combined group,38 patients)or conventional radiotherapy(control group,38 patients).Chemotherapy consisted of Cisplatin,5FU and Bleomycin.3 months aftertreatment,in the primary lesion the complete response rates in the combined group and the control group-were 89.5 % and 97.5%(P>0.05), respectively, whereas for the cervical node complete response rateswere 93.8% and 90. 6%(P>0.05), respectively, Analysis at 3-year did not show significant difference be-tween the combined group and the control group in rates of overall survival (68.4% vs 61.1%,X￣2=0.282),disease free survival(63. 2% vs 48.6%,X￣2=0.735), metastasis free survival(70.7% vs 56.1%,X￣2=1.382), primary lesion control(84.7% vs 77.5%,X2=0.394)and cervical node control (80.1% vs 82.8%,X2=0.383).更多还原