【摘要】 免疫组化研究ｎｍ２３与ｐ２１在８８例胃癌的表达变化与胃癌生物学行为及淋巴结转移的关系。结果发现ｎｍ２３低表达与胃癌侵袭程度显著相关（Ｐｅａｒｓｏｎ列联系数Ｐ＝０．２８，Ｐ＜０．０５）。ｎｍ２３低表达者淋巴结转移率（９２．７％）比正常表达者高（４８．５％，Ｐ＜０．０５）。同时发现ｐ２１阳性染色率为６５．９％，ｐ２１阳性染色与肿瘤组织分型及癌细胞增殖活性呈正相关（Ｐｅａｒｓｏｎ列联系数分别为Ｐ＝０．３８和０．３５，Ｐ＜０．０５），ｐ２１阳性肿瘤的淋巴结转移率（８７．９％）明显高于ｐ２１阴性的肿瘤（５３．３％，Ｐ＜０．０５）。ｎｍ２３低表达和ｐ２１过表达在胃癌淋巴结转移中的表现为独立的联合作用。提示ｎｍ２３低表达和ｐ２１过表达在胃癌淋巴结转移和肿瘤增殖中起重要的作用，ｎｍ２３与肿瘤浸润有关，而ｐ２１与肿瘤组织分型和增殖有关。更多还原

【Abstract】 By using immunohistochemical methods,the relation of the expression of nm23 and p21 tothe biological behavior and metastasis to the lymph nodes in the primary gastric carcinoma(in 88 cases).The results showed that a significant correlation between the lower-expresion of nm23 and the depth ofcancer inrasion was found.nm23 lower-expressive tumours were associated with a higher incidence ofmetastasis to lymph nodes (92.7%)than were nm23-normal expressive(48.5%,P<0.05).Abnormalitiesof p21 expression were found in 65.9% of the 88 primary gastric carcinoma. A significant associations wasfound between p21 over-expression and the morphologic pattern of the tumor and the proliferative activi-ties.The metastatic rate in tumours stained positively for p21(87.9%)were higher than in those with nega-tive p21 staining(53.3%,P<0.05).The contributions of nm23 lower- expression and p21 over-expressionto the lymph nodal metatasis were the independent joint action.It is suggested that nm23 lower-expressionand p21 over-expression played significant role in the metastasis to lymph nodes in the primary gastric car-cinoma.nm23 lower expression related with the cancer invasion p21 over-expression with the morphologicpatitern and proliferative activity of gastric carcinomas.更多还原