【摘要】 用电子自旋共振技术和化学发光（ＣＬ）法研究了川芎嗪（Ｌｉｇｕｓｔｒａｚｉｎｇｅ，Ｌｉｇ）对活性氧自由基的清除作用。Ｌｉｇ２５ｍｌ^－１对两种水溶液体系产生的Ｏ_２^－和ＯＨ－的清除率分别为１００％和４４％。该作用被ＣＬ证实。Ｌｉｇｍｇ２５ｍｇ．ｍｌ^－１对一种脂溶液体系产生的ＬＯＯ的清除达８０％。提示Ｌｉｇ能直接清除具细胞毒性作用的自由基（Ｏ_２^－，ＬＯＯ，ＯＨ－）。更多还原

【Abstract】 The scavenging effects of ligustrazine(Lig)isolated from Ligusticum wallichii Franch on active oxygen free radicals were studied using spin trapping technique and chemiluminescence methods.The scavenging rate of superoxide anion by Lig(25 mg,ml-1)was 100%in xanthine/xanthine oxidase(Xan/XO) system,and that of hydroxyl radical (OH)was 44% in Fenton’s reac tion. The scavenging rate of lipid peroxyl radical(LOO)by Lig (25 mg·ml-1)was 80% in peroxi dizing microsome system, It is possible that Lig scavenged by catalyzing its spontaneous dismuta tion, The results showed that Lig had strong effects of se,avenging cyotoxic oxygen free radicals.更多还原