【摘要】 将日本大耳白兔２７只随机分为３组，观察中药通脉降脂口服液在实验性动脉粥样硬化形成中降低血脂、减轻脂质过氧化损伤、调节前列腺素代谢及减轻粥样斑块形成作用。结果表明：通脉降脂口服液可明显地降低实验动物血清胆固醇（ＴＣ）、甘油三酯（ＴＧ）、血浆脂质过氧化物（ＬＰＯ）及血栓素Ｂ_２（ＴＸＢ_２）的含量，升高全血谷胱甘肽过氧化物酶（ＧＳＨ－ｐＸ）活性，调节血栓素Ｂ_２／６－酮－前列环素(６－ｋｅｔｏ－ＰＧＦ_ｌａ)的平衡，并可使主动脉粥样硬化斑块面积及厚度明显小于胆固醇组。通脉降脂口服液的上述作用可能是其抗动脉粥样硬化作用的主要机制。更多还原

【Abstract】 Japanese white male rabbits were divided into 3 groups for evaluation of Tongmai Jiangzhi Oral Liquor(TMJZ)in reducing the serum cholesterol,the level of plasma lipid peroxidation(LPO),the plasma TXB 2 and suppressing of atherosclerotic plaque formation in atherogenesis.The results indicated that TMJZ not only decreased significantly the levels of serum cholesterol,triglyceride,LPO and TXB 2,but also increased markedly blood glutathion peroxidase(GSH-Px) activity and regulated the balance of TXB2/6-keto-PGF la. The area of atherosclerotic plaque coverage in aorta and the thickness of plaque after oral TMJZ were much smaller than those of high -cholesterol-fed rabbits.It is suggested that the effect of TMJZ on above-mentioned indexes might be important mechanism of its anti-atherosclerotic effect.更多还原