【摘要】 本研究用细菌内毒素（Endotoxin,ET）复制家兔发热模型,观察石膏灌胃对家兔发热效应和脑脊液环核苷酸含量变化的影响。实验发现灌入 ET 后60mim 时,石膏加ET 组动物的平均体温[ΔT℃（0.47±0.10）]和3h 体温反应指数[TRI₃（2.55±0.08）]明显低于 ET 组的ΔT℃（1.23±0.07）和 TRI₃（4.99±0.10）,其差异性均非常显著（P<0.01）。脑脊液环核苷酸（cAMP）含量:石膏加 ET 组（21.75±2.51pmol/ml）明显低于 ET 组（32.51±3.10pmol/ml）差异非常显著（P<0.01）。推论:石膏煎剂灌胃对家兔发热有明显抑制作用,其机制很可能与中枢神经组织中环核苷酸含量变化有关。更多还原

【Abstract】 To investigate the effects of Gypsum on endotoxin （ET）- induced fever and CSF levels of cAMP in rabbits, it was found that Gypsum could inhibit the rise of body temperature caused by ET injection.（ΔT of Gypsum + ET group was 0.47±0.10℃,TRI₃ 2.55±0.08℃:ET group 1.23±0.07℃;TRI₃ 4.99±0.10℃,P<0.01） and that cAMP levels in CSF could be decreased by Gypsum,comparing with that of other groups.（cAMP levels of Gypsum+ET group in CSF were 21.75±2.51 pmol/ml,ET group 32.51±3.10 pmol/ml,P<0.01）.This showed that Gypsum could inhibit ET induced fever.The changes of cyclic nucleotide levels in the central ner- vous system might play a major role in the febrifugal mechanism of Gypsum.更多还原