【摘要】 本研究采用2次注射内毒素诱发家兔弥散性血管内凝血(DIC)以模拟温病血分证模型获得成功。模型家兔呈现高热神昏、呼吸急促、舌质红绛、内脏出血等变化,且有显著的血液学和病理学变化。作者认为温病血分证与内毒素 DIC十分吻合,以家兔内毒素DIC 作为温病血分证模型具有发病时相上的齐同性,病理本质的一致性和病变程度的均衡性等优点,尤其适用于筛选防治温病血分证的古方验证。更多还原

【Abstract】 The rabbits with disseminated intravascular coagulation (DIC) which was thought to imitate the models for Xuefen Syndrome (XFS) of febrile disease were successfully established by twice intravenously injecting endotox- in.The high fever,lethargy,dyspnea,crimson tongue and splanchnic bleeding in rabbits of model group were observed.Furthermore,it was also noticed that significant hematological disturbance and pathologic lesions oc- curred in the animals.Therefore,it is suggested that XFS of febrile disease in TCM would coincide with endo- toxic DIC in modern medicine.It is considered that regarding the rabbits with endotoxie DIC as the animal model for XFS of febrile disease would be of main advantages such as uniformity in the phase of disease,unanimity in the nature of pathogenesis and identity in the degree of pathological changes etc.in the suffered animals,and is especially adaptive to test the ancient or effective prescriptions preventing or treating XFS of febrile disease.更多还原