【摘要】 用无水乙醇制备大鼠急性胃粘膜损伤模型,丹参水溶液预先给药作为胃粘膜保护剂,观察丹参对乙醇性急性胃粘膜损伤的影响。结果显示丹参组胃粘膜损伤指数(19.46±1.14mm)明显低于乙醇组(71.42±1.23mm),P<0.01。组织学观察结果证实丹参组Ⅱ级和Ⅲ级损伤率明显低于乙醇组(P<0.05,P<0.01)。结果说明丹参对大鼠乙醇性急性胃粘膜损伤有保护作用。两种给药途径比较显示,胃饲优于静脉给药;剂量实验表明,丹参的胃粘膜保护作用呈剂量依赖关系。更多还原

【Abstract】 This study was performed to determine the protective effect of Salviae miltiorrhiza(SM)on acute gastric mucosal damage induced by ethanol in rats.Acute gastric mucosal damage was induced by intragastric ethanol in- stillation.The reaults showed the administration of SM solution before ethanol instillation caused a significant reduction of mucosal damage.Histologic analysis showed SM solution treatment before ethanol challenge reduced Ⅱ and Ⅲ grade damage rate was lower than that in ethanol group.These reaults clearly showed that SM solu- tion orally administered to rats could prevent hemorrhagic necrotic lesions of gastric mucoses induced by ethanol.更多还原