【摘要】 对亚胺培南与其它6种头孢菌素对888株临床致病菌的抗菌谱及耐药率进行了比较。对于大部分需氧菌和脆弱拟杆菌,亚胺培南显示了强大的抗菌活性,特别对于部分对其它6种头孢菌素耐药的菌株也具有很好的抗菌活性。2mg/L以下的亚胺培南可以抑制90％菌株的生长。对于大肠杆菌、克雷伯肺炎杆菌、痢疾志贺氏菌、沙门氏菌属、奇异变形杆菌、产气肠杆菌,亚胺培南与头孢噻肟、头孢他定、头孢曲松的抗菌活性相似;对于阴沟肠杆菌、枸機酸杆菌属、沙雷氏菌属、不动杆菌属、金葡菌、表皮葡萄球菌、化脓性链球菌、肺炎链球菌、粪链球菌及脆弱拟杆菌,亚胺培南的抗菌活性强于其它6种抗生素。根据美国临床实验室标准全国委员会(NCCLS)推荐的标准进行耐药性调查的结果显示,本实验中细菌对亚胺培南的耐药率最低。更多还原

【Abstract】 Imipenem was compared with other six cephalospirins against 888 clinical isolates including most of the aerobic and bacteroides fragilis by the dilution method. Imipemen exhibited great activity against all isolates tested in our test. The strains were recentelinical isolates,many of which were relatively resistant to other an-tibictics. Concentrations of 2mg/L or less of imiperem inhibited 90% of 888 clinical isolates. The activity of imipenem against Escherichia coli, Klebsiella pneumoniae, Shigella dysenteriae. Salmonella spp., Proteus mirabilis, Enterobacter aerogenes was essentially similar to that of cefotaxime, ceitazidime and ceftriaxone. Against Enter-obacter cloacae, Citrobacter spp. , Serratiaspp. , Acinetobacter spp, , Staphylococci au-revs, Staphylococci epidermides, Streptococci pyogenes, Streptococoi pneumoniae. Streptococci faecalis and Bacteroides fragilis, imipenem was more active than other antibiotics. Statistical results showed the lowest bacteria resistant rate to imipenem among tested drugs according to the standards of National Committee for Clinical Laboratory Standards (NCCLS).更多还原