【摘要】 采用成熟精子计数、精子畸形分析和定量组织学的方法．研究了甲基汞慢性染毒对雄性小鼠生精过程的影响。研究结果表明：甲基汞损伤雄鼠生精过程，使成熟精子数量减少，精子畸型率增高。这种损伤作用与甲基汞染毒剂量及甲基汞在雄鼠体内的蓄积量有关。定量组织学分析发现：慢性甲基汞染毒可使小鼠曲细精管截面积减小，管内生殖细胞数量降低。定量组织学分析结果与病理观察及精子分析结果完全吻合。更多还原

【Abstract】 Using count of sperm, analysis of abnormality and quantitative histology methods, influence of chronic treatment of methylmercury (MeHg) on spermatogenesis of male mice was studied. Results indicated that methylmercury could damage spermatogenesis of male mice, decrease count of sperm and increase abnormality of sperm. The damage effects related with doses of MeHg administration and amounts of MeHg accumulated in male mice. Results of quantitative histology showed that chronic treatment of MeHg decrease of seminiferous tuble and count of germ cell of male mice. The results were entirely consistent with conclusion of pathologic observation and analysis of sperm.更多还原