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电针对实验性单发关节炎模型的镇痛及治疗作用

EFFECTS OF ELECTROACUPUNCTURE ON A MODEL OF ACUTE UNILATERAL INFLAMMATION OF THE HINDPAW IN PATS

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【作者】 罗非许伟韩济生

【Author】 LUO Fei;Xu Wei;HAN Ji-Sheng(Neuroocience Research Center,Beijing Medical University,Beijing 100083)

【机构】 北京医科大学神经科学研究中心

【摘要】 利用白陶土及鹿角菜胶在大鼠足底注射,构成局限性急性单发关节炎模型,探讨电针对该模型的作用。实验动物在戊巴比妥钠麻醉下,足底注射4%白陶土混悬液0.1ml及2%鹿角菜胶溶液0.05ml,致炎后于第4~12小时炎症显著。不同参数的电针刺激均可产生镇痛效应,其中2/15Hz电针的针效最高,并有明显的后效应(治疗作用)。单次电针已能产生足够的治疗作用,反复电针仅能使此作用略有加强。单纯留针亦有一定治疗作用。

【Abstract】 An acute unilateral inflammation was induced in the right hindpaw of rats,in an attempt to observe the analgesic and therapeutic effect of electroacupuncture(EA)on this model.Unilateral intraplantar injection of 4% kaolin 0.1 ml and 2% carrageenan 0.05ml into the right hindpaw of rats under pentobarbital anesthesia led to a localized inflammation that became apparent within 2 hours and plateaued between 4~12 hours.Marked analgesia was observed at the inflammed leg by administered at hind leg of the healthy side.Among different frequencies being used,EA of 2/15 Hz showed the best analgesic effect during the stimulation period and after the cessation of EA,the later may be considered as a curative effect on the arthritic model.Single session of EA for 30 min was enough to produce the curative effect which was further enhanced by the repeated administration of EA.A significant although relatively weak effect can be induced by needle insertion without stimulation.The possible mechanisms of the immediate and longer lasting effect of EA were discussed.

【关键词】 电针镇痛关节炎动物模型
【Key words】 Electrocaupuncture analgesiaArthritisAnimal model
【基金】 国家中医药管理局基金,美国NIDA基金
  • 【文献出处】 中国疼痛医学杂志 ,CHINESE JOURNAL OF PAIN MEDICINE , 编辑部邮箱 ,1995年01期
  • 【分类号】R684.3
  • 【被引频次】25
  • 【下载频次】147
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