【摘要】 缺血性中风患者血清抗心磷脂抗体检测及其临床意义许贻白，诸金水，张国屏，沈翠芬（湖州市第二人民医院神经内科，湖州３１３０００）１９８３年Ｈａｒｒｉｓ等［１］首次用放免法测定抗心磷脂抗体（ＡＣＡ），并证明其和系统性红斑狼疮（ＳＬＥ）并发血栓形成有关，近年...更多还原

【Abstract】 AbstractIn 70 patients with ischemic cerebrovascular disease(ICVD) level of serum anticardi olipin antibodies(ACA)were determined by enzyme-linked immunosorbent assay,and plas ma lupus anticoagulant by activated partial thromboplastine time.22 patients with nonis chemic neurologic disorders(NIND) and 35 healthy subjects were taken as controls. Results showed that the mean binding index of IgM ACA of patients with ICVD was significantly higher than those of patients with NIND and healthy controls(0.99± 0.34 vs 0.71±0.28,0.61±0.14). 16 patients(22.86%)had positive ACA: 14 patients for IgM ACA and 2 for IgG ACA,about 50% of these patients associated positive ACA had positive LAC, 25%pa tients associated positive ACA had no other stroke risk factors or heart diseases. It suggest ed that ACA was related to ICVD and appeared to be a risk factor for ischemic stroke. Data from this study showed that ACA associated patients shared several clinical characteristics:these patients were predominantly female,frequently in younger individuals,more likely to have recurrent or multiple infarcts, vertebrobasilar ischemia more often and particularly co existed with cardiac disease. Potential mechanisms of ACA in the pathogenesis of cerebral is chemia and its relation to fibrinolytic coagulant system were discussed briefly.更多还原