节点文献
瘤苗特异性主动免疫治疗及其机制的实验研究
Experimental Study on the Immunoprotective Effect and Mechanism of Action of Specific Active Immunization with Tumor Cell Vaccine
【摘要】 围绕中药莪术及其有效成分β-榄香烯的抗癌作用与原理的研究,用多种小鼠可移植性瘤株,比较系统、深入地研究了中药(莪术油、β-揽香烯等)、化学药品(MMC、戊二醛等)、放射能(60Co、X线等)及/或病毒(痘苗病毒、新城鸡瘟病毒)等处理的肿瘤细胞疫苗或其膜组分(Mfr)的主动免疫防治效应及其规律和机制,获得了明显的可重复的阳性结果,解决了有关瘤苗制备、保存和使用方法等一系列问题.
【Abstract】 Through several murine transplantable tumor models, we studied the immunoprotective effect and mechanism of action of specific active immunization with various tumor cell vaccines (TCV) treated by: (1) Oleum Curcuma Aromatica (OCA, a Chinese anticancer medicament) and its effective monomer β-elemene; (2) MMC and glutaraldehyde; (3) 60Co and X-ray irradiation; and (4) vaccinia virus (VV) and newcastle disease virus (NDV), including virus infected TCV membrane fraction (Mfr). The reproducible results of immunoprotective effect indicated that the specific active immunotherapy with such TCVs might be of practical value in clinical immunological approaches to cancer therapeutics.
【Key words】 tumor cell vaccine; specific active immunotherapy; Oleum Curcuma Aromatica; β-elemene;
- 【文献出处】 中国肿瘤生物治疗杂志 ,Chinese Journal of Cancer Biotherapy , 编辑部邮箱 ,1995年02期
- 【分类号】R730.51
- 【被引频次】54
- 【下载频次】103