【摘要】 胃癌单克隆抗体（McAb）3H11具有高阳性反应率、高选择性及高亲和力的特点.以¹³¹I标记后注入荷胃癌裸鼠模型中,其瘤/肝比可达8.26±1.26,定位指数达6.08 ±1.51,ID%/g达11.00±2.62.该McAb与¹³¹I偶联后可明显增强后者对肿瘤的杀伤效应及减低毒副反应.¹³¹I标记的McAb 3H11静脉注入19例拟行手术的胃癌患者中,16例获阳性显像（84.2%）.经胃镜引导注入癌旁粘膜下行胃癌放射免疫导向手术,判别胃壁肿瘤浸润的灵敏度、特异性及准确率分别为946%,967%及959%.判别淋巴结转移的上述指标分别为99.2%、97.7%及98.8%.更多还原

【Abstract】 A monoclonal antibody (McAb) 3H11 against gastric cancer with high positive rate, high selectivity and high affinity was obtained. 131 I Labeled McAb 3H11 was injected into gastric cancer-bearing nude mice, and the tumor/liver ratio, localization index, ID%/g could reach 8.26±1.26, 6.08 + 1.51, 11.00±2.62, respectively. Moreover, McAb 3H11 conjugated with 131 I could increase the cytotoxicity to tumor xenografts and decrease the side effects. The radioimmunoimage was carried out in 19 cases with gastric cancer, and positive image was obtained in 16 cases (84.2%). The radioimmunoguided surgery of gastric cancer was successfully done by submucous injection of labeled McAb 3H11 through endoscope. The sensitivity, specificity and accuracy for evaluation of tumor infiltrated gastric walls were 94.6%, 96.7% and 95.9%, respectively. The sensitivity, specificity and accuracy for identification of metastatic lymph nodes were 99.2% ,97.7% and 98.8%, respectively.更多还原