【摘要】 为研究血管紧张素转换酶抑制剂对血管与血压作用之间的关系，选用２组自发性高血压大鼠（ＳＨＲ），从胚胎期每天分别给予卡托普利２０ｍｇ／ｋｇ（Ａ组）与１００ｍｇ／ｋｇ（Ｂ组），至１６周龄停药。测定左心室重量／体重比，肠系膜动脉ＩＩＩ级血管与肾动脉的血管壁／管腔比，并同时观察后肢阻力血管灌注模型对苯肾上腺素的灌注压反应曲线。实验证明两种剂量卡托普利均能防止血管壁肥厚。停药后Ａ组血压迅速回升为２７．７±２．６ｋＰａ（２０４±２０ｍｍＨｇ），Ｂ组血压维持在较低水平２０．１±１．２ｋＰａ（１５２±９ｍｍＨｇ），但均高于对照ＷＫＹ大鼠１６．５±１．６ｋＰａ（１２４±１２ｍｍＨｇ）。灌注压反应曲线在Ｂ组与对照ＷＫＹ组相同。在灌注液内分别加入硝基。精氨酸甲基酯（Ｌ－ＮＡＭＥ）和Ｌ－精氨酸，卡托普利能抑制ＳＨＲ对Ｌ－ＮＡＭＥ过强的血管收缩反应，增强Ｌ－精氨酸的血管收缩性减弱的作用。卡托普利治疗引起的血管结构与反应性的改变可以不依赖于血压下降的效果，临床上应用卡托普利降压不明显的病人继续使用卡托普利可有助于改善血管功能。更多还原

【Abstract】 HRs were given captopril 20 mglkglday (groupA , n= 13) and 100 mg/kg/day (group B , n=17) fromintrauterus peritxl to 16 weeks of age, then the treat-ment was removed. Experiments were carried out at 40weeks. SBP, left ventricular masslbody weight ratio,wallllumen ratio of branch III mesenteric and renalartery were determined. The perfusion pressure re-sponse to ai adrenergic agonist (phenylephrine) of resis-tance blood vessels in a hindquarter model in the pre-ence of Nw -nitro-1-arginine-methyl ester (LNAME) orLarginine were examined. Untreated SHR (n = 16)and untreated WKY (n= 17) served as controls. Bothdoses of captopril treatment completely prevented hyper-trophy of vascular vessels to some extent comparable tothat of the untreated WKY. But their SBP was still sig-nificantly higher than that of the untreated WKY. Thecurves of perfusion pressure responding to incrementaldoses of phenylephrine shifted rightward in the captopriltreatment groups in a dose dependent manner. Thecurves of high dose group were almost identical to thoseof WKY , markedly different from that of the untreatedSHR. Captopril decreased the over enhanced vasocon-strictor effect of LNAME in SHR. The attenuated vaso-constrictor effect by L-arginine was greatly augmentedby captopril, suggesting that captopril improves thefunction of resistance of vessels by mediating endothelialcells. Captopril-induced alteration in vascular structureand function may be separated from its hypotensive ef-fect. Clinically, continuing administration of captoprilmay be beneficial to the improvement of the vascularsystem in those blood pressure unresponsive patients.更多还原