【摘要】 分析了７７例３３岁以下肝癌患者（青年组）的临床病理表现，并与同期６０３例３５岁以上肝癌患者（老年组）比较，以探讨进一步提高青年肝癌患者疗效的途径。青年肝癌患者主要特点是：（１）普查发现者较老年组少（分别为１５．６％，２８．７％，Ｐ＜０．０５），（２）有肝炎病史者较老年组少（３６．８％，６６．３％，Ｐ＜０．０１），（３）血清ＨＢｓＡｇ阳性行较老年组多（７９．２％，６７．６％，Ｐ＜０．０５），（４）合并肝硬化者较老年组少（６４．９％，９０．７％，Ｐ＜Ｏ．０１），（５）肝癌＞５ｃｍ者较老年组多（８７．０％，７３．０％，Ｐ＜０．０１），（６）肝癌病期较老年组晚（ＴＮＭⅢ期肝癌，２９．９％，１８．２％，Ｐ＜０．０５），（７）血清ＡＦＰ值较老年组高（ＡＦＰ＞４００μｇ／Ｌ，７１．４％，５４．６％，Ｐ＜０．０１）。说明青年肝癌患者确诊时病期较晚，肿瘤较大，ＡＦＰ值较高；ＨＢｓＡｇ阳性率高、合并肝硬化少，提示ＨＢｓＡｇ可能在青年肝癌致癌因素中起重要作用；对ＨＢ－ｓＡｇ阳性的青年患者进行定期随访（ＡＦＰ和Ｂ超），有助于肝癌的早期发现和早期治疗，以进一步提高治疗效果。更多还原

【Abstract】 o investigate clinicopathologic characteristics ofprimary liver cancer (PLC) in young adults, 77 patientsyounger than 35 years were compared with 603 patientsolder than 35 years during the same period. In theyoung patients, PLC showed a low incidence of PLC de-tected at mass survey (young 15. 6% versus older 28.7% . P<0. 05); a low incidence of hepatitis history(young 36. 8% versus older 66. 3%, P<0. 01 ); a highincidence of positive hepatitis B virus surface antigen(HBsAg) (young 79. 2% versus older 67. 6%,P<0.05); a low incidence of associated cirrhosis (young 64.9% versus older 90. 7%, P<0. 01); larger tumor size(PLC>5cm; young 87. 0% versus older 73. 0% , P<0. 01);a more advanced stage of the disease in TNMclassification (stage Ⅲ; young 29. 9% versus older 18.2% , P<0. 05). It is suggested that hepatitis B virus(HBV) may play an important role in the developmentof PLC without associated liver cirrhosis in the youngpatients. A close periodic surveillance of young adultswith a positive HBsAg is important to detect PLC at anearly stage.更多还原