【摘要】 在２４３例中国人中研究两个糖代谢途径限速酶基因，己糖激酶Ⅱ基因（ＨＫ２，骨胳肌）及磷酸烯醇式丙酮酸羧激酶基因（ＰＣＫ１，肝）的微卫星多态性及与非胰岛素依赖型糖尿病（ＮＩＤ－ＤＭ）的关系。结果表明：（１）普通群体中，ＨＫ２微卫星多态标志等位基因频率在不同地区中国人群体间及中国人与白种人间无差异；（２）ＰＣＫ１频率在不同地区中国人群体间无差异，但中国人与白种人间存在差异；（３）中国人ＮＩＤＤＭ全组及亚组与相应对照组比较中，ＨＫ２频率无差异；（４）ＰＣＫ１等位基因频率在糖尿病家族史及起病年龄亚组比较中存在差异。揭示：（１）ＨＫ２与中国人ＮＩＤＤＭ无关联；（２）ＰＣＫ１与中国人ＮＩＤＤＭ部分亚群有关。更多还原

【Abstract】 The characteristics of microsatellite polymorphisms of carbohydrate metabolic pathway ratelimiting enzyme genes, hexokinase Ⅱ gene (HK2) and phosphoenolpyruvate carboxykinase gene(PCK1), and their relations to NIDDM were studied in 243 Chinese. The survey showed: (1) no difference of the allelic frequency distribution of HK2 microsatellite polymorphisms was observed between Chinese general populations from different areas and between Chinese and Caucasians; (2) there was no difference of PCK1 microsatellite polymorphisms between Chinese from different areas, yet significant frequency difference was observed between Chinese and Causasians; (3) no difference of the allelic frequency of HK 2 was noted between Chinese NIDDM and control as a whole and as subgroups; (4)the allelic frequencies of PCK1 were significantly different in the diabetes-family history subgroup and age-of-onset subgroup comparisons in Chinese.The results suggested that HK2 was not associated with Chinese NIDDM, but PCK1 was associated with subgroups of Chinese NIDDM.更多还原