【摘要】 用单克隆及多克隆双抗体夹心ＥＬＩＳＡ法测定１５例正常小儿及４６例不同贫血患儿血清可溶性转铁蛋白受体（ｓＴｆＲ），发现不同贫血患儿ｓＴｆＲ水平与对照（４．５４±１．０８ｍｇ／Ｌ）相比有显著性差异，溶血性贫血组（９．９４±３．３２ｍｇ／Ｌ）与缺铁性贫血组（１３．９２±４．４５ｍｇ／Ｌ）显著升高；再生障碍性贫血（再障）组（２．０６±０．８２ｍｇ／Ｌ）显著降低，纯红再障最低，重型再障显著低于慢性再障值。ｓＴｆＲ水平可由机体含铁状况和红系生成率共同决定，在诊断缺铁及再障的病情预后估计方面有一定临床价值。更多还原

【Abstract】 erum transferrin receptor (sTfR) was determined bythe method of sandwich ELISA using monoclonal andpolyclonal antibodies in 15 normal children and 46 pa-tients with various anemias. There was a significant dif-ference between normal children and anemic subjects.The mean concentration of sTfR in normal children was4. 54 ±1. 08mg/L, and it was sharply elevated in pa-tients with hemolytic and iron deficiency anemia, butwas markedly reduced in patients with aplastic anemia .The lowest level was observed in two patients with purered cell aplasia and the level was much lower in patientswith severe aplastic anemia than that with chronic aplas-tic anemia. It is concluded that the serum concentrationof sTfR is defined by both iron status and erythropoiesisrate. Serurn sTfR may be of clinical value in the diagno-sis and prognosis of iron deficiency and aplastic anemia.更多还原