【摘要】 测定无症状心肌缺血（ＳＭＩ）组（１５例）、心绞痛组（１１例）和对照组（７例）运动试验前后血浆组织胺和５－羟色胺的含量，并观察了５－羟色胺拮抗剂赛庚啶的效应。结果显示：运动前ＳＭＩ组血浆组织胺含量明显低于心绞痛组和对照组（Ｐ＜０．０５），运动后三组之间差异无显著性（Ｐ＞０．０５），运动前三组血浆５－羟色胺含量差异无显著性，运动后心绞痛组明显高于ＳＭＩ组和对照组（Ｐ＜０．０５）。心绞痛组（６例）服用赛庚啶后再次运动试验，在两次运动试验各参数和血浆５－羟色胺含量差异无明显性的状况下，６例心绞痛病人中有３例心绞痛症状消失。提示：组织胺在ＳＭＩ和心绞痛发生中的作用差异无显性，高血浆５－羟色胺可能参与了心绞痛的发生，而心肌缺血时无症状可能与血浆中５－羟色胺含量未升高有关。Ｐ＜０．０１；心绞痛组与ＳＭＩ组和对照组比较：△Ｐ＜０．０５；ＳＭＩ组与心绞痛组和对照组比较：▲Ｐ＜０．０５参考文献更多还原

【Abstract】 Abstract The study was designed to evaluate the role of plasma 5-hydroxytryptamine (5-HT) and histamine in silent myocardial ischemia (SMI) and angina pectoris,and the effect of cyproheptadium-an antagonist of 5-HT. In 15 patients (group 1) with SMI, 11 patients (group 2) with effort angina and 7 healthy controls (group 3), the plasma levels of 5-HT and histamine were measured by fluorometry both in resting state and immediately after exercise test. No statistical difference in resting plasma 5-HT levels among the three groups was found. However, after exercise,the plasma levels of 5-HT in group 2 was significantly higher than those in groups 1 and 3 (P<0.05). The resting plasma level of histamine in group 1 was significantly lower than those in groups 1 and 3 (P<0. 05), however, after exercise, no statistical difference in plasma histamine levels among the three groups was found. Six patients of group 2 were treated with cyproheptadium, and then exercise test was repeated, all exercise tests were still positive, it was very interesting to find that no angina pectoris was induced in 3 of the 6 patients. The results suggest that painful myocardial ischemia may be related to the increase of plasma level of 5-HT, and painless myocardial ischemia to the unchanged plasma level of 5-HT , while no significant difference was found in plasma histamine levels between painless and painful myocardial ischemia.更多还原