【摘要】 20例非肥胖的高血压病(EH)患者卡托普利治疗前及治疗12个月后,分别进行口服葡萄糖耐量试验(OGTT),并测定治疗前后的血糖、血浆胰岛素,血胆固醇、甘油三脂,血尿酸、肌酐、尿素氮等,与14例正常人(其年龄、体重指数相当)比较.结果:两组空腹血糖及糖耐量无明显差异(P均>0.05)、均正常.EH组空腹及OGTT后30、60、120分钟血浆胰岛素显著升高(P均<0.05).卡托普利治疗后12个月,空腹及OGTT 30、60分钟血浆胰岛素下降,60分钟较明显(P<0.05).提示EH患者存在高胰岛素血症;卡托普利长期治疗后,降压的同时高胰岛素血症也得到了某些改善.更多还原

【Abstract】 An oral glucose tolerance test (OGTT) was performed on 20 non-obesity patients with essential hypertension (EH ) , before and after captopril treatment, and campared with 14 normal subjects (matched with age and body mass index). The plasma glucose and insulin concentration of 0-, 30-, 60-, 120-minute at OGTT and the SGPT, cholesterol, triglyceride, uric acid serum creatinine, blood urea nitrogen were measured. The results demonstrated the plasma glucose concentration and response to OGTT were not significantly different in both groups (P>0. 05). But in EH group the fasting and OGTT 30-, 60-, 120-minute plasma insulin level were higher than those in normal group (P<0. 05). After 12 months of capto- pril treatment, the 0-, 30-, 60-minute plasma insulin level decreased, but the 60-minute level was more obvious (P<0. 05). This suggests that there are hyperinsulinemia in patients with EH, and hyperinsulinemia has some improvement after long-term treatment with captopril. The potential mechanisms was briefly discussed.更多还原