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小儿神经母细胞瘤DNA含量、N-myc基因扩增与临床预后的关系

Relation Among DNA Content,N-myc Gene Amplification and the Clinical Prognosis

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【作者】 刘荻吴建新呼守生马汝柏林久治

【Author】 Liu Di;Wu Jainxin;Hu Shousheng;et al.(The Capital Institute of Pediatrics,Beijing 100020)

【机构】 首都儿科研究所病理室

【摘要】 本文比较分析了18例神经母细胞瘤的DNA含量、N-myc基因扩增、临床分期、原发部位等因素与预后的关系。结果表明,有N-myc基因扩增的死亡率(7/10)明显高于无扩增的(1/8);DNA、含量增高与肿瘤的恶性度成正比;临床分期与N-myc基因扩增情况相结合与病死率的关系极为密切。

【Abstract】 In this study,18 children with neuroblastoma were analysed on the relation among DNA content,N- myc gene amplification and the clinical staging.The results reveal:the mortality of patients with N-myc gene amplification(7/10)was higher than those without N-myc gene amplification(1/8);DNA content was related to malignancy of the tumor.combination of N-myc gene amplification and the clinical staging kept close link with the prognosis.

  • 【文献出处】 中华小儿外科杂志 ,CHINESE JOURNAL OF PEDIATRIC SURGERY , 编辑部邮箱 ,1995年05期
  • 【分类号】R730.264
  • 【下载频次】70
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