【摘要】 氧氟沙星的合成中间体苯并嗪［（±）１］先与（Ｓ）－Ｎ－对甲苯磺酰脯氨酰氯反应，经结晶分离，其母液（２ａ）水解后所得游离碱（１ａ）再与（１Ｓ）－（＋）－１０－樟脑磺酸成盐，重结晶后的盐（３）碱析得所需（Ｓ）－苯并嗪［（－）１］。更多还原

【Abstract】 Crystallization of the diastereoisomers [(+)2 and (-)2] formed from (± ) - 7, 8-difluoro-3, 4-dihydro-3-methy1-2H- [1, 4] -benzoxazine [ (±) 1] with (S)-N-(p-toluenesulfonyl) prolinyl chloude, there was obtained 2a [rich in (+)2]. Hydrolysis of 2a gave 1a [rich in (-) 1] which was resolved by(1s)-(+)camphor-10-sulfonic acid to afford the required (-) 1.更多还原