【摘要】 近年动物试验证明心肌缺血预适应有一种保护作用。本组分析了近３年我院急性前壁心肌梗塞１１０例病人缺血预适应对心肌梗塞的影响。其中男７７例，女３３例。心肌梗塞前有预缺血者６９例（Ａ组）．，无预缺血者４１例（Ｂ组）。资料分析显示：Ｂ组心肌梗塞时心肌坏死范围、心肌酶峰值、心功能损害、室壁瘤形成及死亡率均高于Ａ组，两组差异有显著性。还就心肌缺血预适应发生时间及其对心肌保护作用之间的关系，缺血预适应的可能机制及临床意义进行了讨论。更多还原

【Abstract】 he protective effect of ischemic preconditioning has heen confirmed in animal models. In this study we analyzed the clinical data of 110 cases of acute myorardial infarction(77male, 33 female). Sixty-nine cases(group A)had ischemic manifestations prior to myocardial infarction,while forty one (group B)did not have. Our data showed that the cIinical features in group B were quite different as compared with those in group A :(1)larger infarct size (ratio between necrotic size and ischemic size:71.55± 3.70 to 4l.65± 3. 96,P<0. 0001);(2)higher peak level of serum cardiac enzymes(CPK:2085. 78±265. 57 to 1329.80 ±189.44,P<0. 01; CK-MB:102. 73±12. 47 to 47. 38±8. 83, P<0. 01);(3)pcoier cardiac function [LVEF<0.45: 12/41 (29.3%)to 6/69(8.7%), P<0. 05] ; (4) higher incldence of left ventricular aneurysm[9/41 (22.0%)to 3/69 (4.3%), P<0.05] and(5)higher mortality rate in 4 weeks[6/41(14.6%)to2/69 (2.9%),P<0. 05].The difference between the two groups is statistically significant.In addition,the effect of the duration of preconditioning on protection of myocardium,the potential mecha nism of preconditioning and its clinical significance were discussed.更多还原