【摘要】 报道２０例颅脑手术中应用国产尼莫地平控制性降压的初步体会。结果表明，颅脑手术中静滴０．０２％尼莫地平，初速为６００～８００ｕｇ／ｍｉｎ，可使平均动脉压降至并维持在７．３～８．０ｋＰａ，降压维持时间３０～６０分钟，尼莫地平总量４～１２ｍｇ。降压期间收缩压下降３１．６％～３５．６％，舒张压下降３６．１％～４１．９％。平均动脉压下降３３．０％～３７．７％，以舒张压下降幅度最大，降压效果良好，减少了术中出血。停药后１５～３０分钟血压自动回升到降压前水平，未发生“反跳性”血压升高。更多还原

【Abstract】 To assess the controlled hypotension (CH) induced by nimodipine (made in China),twenty patients,aged between 14 and 60 years,ASA class I to Ⅱ,undergoing craniotomy were infused intravenously with 0. 02% nimodipine solution,the total dose range from 4 to 12mg,at a rate of 600-800mg. min-1. The results showed that after nimodipine administration,the systolic,diastolic and mean arterial pressure (SAP,DAP, MAP ) decreased significantly respectively by 31.6%-35.6%, 36.1%-41.9% and 33. %- 37. 7 % (P<0.01 ). MAP was markedly descended to and maintained at the level of 7. 3-8. 0 kpa during the period between 30 and 60 mins(p<0. 01),and HR remained stable during the whole procedures. The intraoperative blood oss was greatly reduced.Fol Following the with4rawal of nimodipine administration,the blood pressure was gradually ascended to the normal level in the period between 15 and 30 mins without the rebounding response. It is suggested that nimodipine can produce effectively the status of the controlled hypotension during craniotomy,which is especially advantageous to the patients with the high levelof HR.更多还原