【摘要】 在１１例接受右心漂浮导管检查的慢性阻塞性肺疾病（慢阻肺）患者中，静脉注射青心酮（ＤＨＡＰ）后肺动脉平均压下降约１５％，肺血管阻力下降３９％，体循环阻力下降２１％，而心输出量上升２７％，体动脉血压及血气无改变。放射免疫测定也表明，用药后血浆内皮素１（ＥＴＩ）及环磷酸鸟苷（ｃＧＭＰ）水平下降（Ｐ＜０．０１，Ｐ＜０．０５）。上述研究表明，青心酮能降低肺血管阻力，其药理机制可能与降低血浆ＥＴＩ水平及调节环磷酸腺苷／环磷酸鸟苷（ｃＡＭＰ／ｃＧＭＰ）ｔｅ值有关。更多还原

【Abstract】 emodynamic parameters were measured by ballontipped catheter in 11 patients with COPD and plasmalevels of endothelinl (ET1)i , cAMP and cGMP weredetected by radioimmunoassay. The results indicatedthat 3 , 4-dihydroxyacetophenone (DHAP) gives with aniv dose of 640mg could reduce (1) 15% of mean pul-monary arterial pressure, 39% of pulmonary vascularresistance and 21% of systemic vascular resistance ; (2)but not effect on systemic arterial pressure and blood gasanalysis ; (3) decrease the plasma ETI as well as cGMPlevel (P<0. 01, P<0. 05 respectivelyl. The authorsthink that the decrease of pulmonary arterial pressure inCOPD patients may be related to the fowering of plasmaETl ievel and the change of the cAMP to cGMP ratio.更多还原