【摘要】 对２８例未经任何治疗的中晚期原发性肝癌患者进行免疫功能的检测，并与正常对照比较，结果发现其ＩＬ－２系统中ＩＬ－２产生能力显著性降低，Ｔ淋巴细胞ｍＩＬ－２Ｒ表达非常显著性降低，而血清ｓＩＬ－２Ｒ水平非常显著性增加；外周血淋巴细胞绝对数及Ｔ淋巴细胞亚群分析表明前者明显降低，ＣＤａ４＋细胞、ＣＤ４＋／ＣＤ８＋比值非常显著性降低，ＣＤ８＋细胞呈显著升高，相关性分析表明：ｓＩＬ－２Ｒ水平与ＣＤ４＋细胞、ＣＤ４＋／ＣＤ８＋比值呈明显负相关（分别为ｒ＝－０．５６，Ｐ＜０．０５；ｒ＝－Ｏ．６７，Ｐ＜０．０５），与ＣＤ８＋细胞呈明显正相关（ｒ＝０．６２，Ｐ＜０．０５）；细胞免疫功能检测表明ＮＫ活性、ＡＮＡＥ阳性Ｔ淋巴细胞数、淋巴细胞转化率显著降低，而ＬＡＫ细胞活性呈非常显著性降低。结果提示肝癌患者机体的细胞免疫、细胞因子及其受体间网络调节紊乱或失调，免疫功能状态严重受损，如何提高其免疫功能是治疗成败的关键。更多还原

【Abstract】 he immunological condition in 28 untreated patients with hepatic cell carcinoma(HCC)have been investigated in this paper.The results showed that IL-2 production, lymphocyte count, NK activ- ity, ANAE positive T lymphocyte and lymphocyte transformation in patients were apparently lower than those in normal controls (NC,P<0.05);membranous IL-2 receptor (mIL-2R),CD4+cell groups,CD4+/CD8+atio,LAK activity of patients were also signiflcantly lower than those of NC(P<0.0l),but CD8+cell groups,soluble IL-2 receptor (sIL-2R) of patients were higher than those of NC(P<0.05 and P<0.01 respectively).It should be noted that CD4+cell groups and CD4+/CD8+ ratio of patients were negatively correlated to slL-2R(r=0.56,P<0.05;r=0.67,P<0.05 respectively),hile CD8+ cell groups of patients were positively correlated to sIL-2R(r=0.62,P<0.05).It suggested that regulation of cell immune cytokine and their receptors in patients were irregular,and State of immune system was unnomal.更多还原