【摘要】 以Ａｌｌｅｎ法造成脊髓损伤模型，对照组仅做椎板切除。伤后静脉注射水杨酸钠１００ｍｇ／ｋｇ体重。于４小时后采用高效液相色谱加电化学检测技术测定脊髓组织二羟苯甲酸含量。结果表明，损伤组２，３－与２，５－二羟苯甲酸含量高于对照组，其中以２，５－二羟苯甲酸最为明显（Ｐ＜０．００１），从而提示脊髓损伤后有大量羟自由基形成，进一步证实自由基确实参与了脊髓损伤的病理过程。更多还原

【Abstract】 AbstractSpinal cord injury (SCI) was induced by Allen’smethod .Sodium salicylate ,100mg/kg,was given IV,immediately after SCI.The level of dihydroxybenzoicacid(DHBAs)of spinal cord was measured by high pres-sure liquid chromatography with electrochemical method.The result indicated that the 2,3-DHBA and 2,5-HDBAin the injuried group were higher than that in the controlgroup . There was a remarked alteration in 2,5-DHEA.The result demonstrated that there was a large amount offormation of ·OH after SCI.更多还原