【摘要】 对 1 8 0例食管癌进行放疗加化疗前瞻性随机分组研究 ,由于部分病例丢失 ,可分析病例1 37例。治疗分 4组 :Ⅰ组、单纯放射治疗 ,32例 ;Ⅱ组、平阳霉素加放射治疗 ,37例 ;Ⅲ组、顺铂加放射治疗 ,4 0例 ;Ⅳ组、平阳霉素加顺铂加放射治疗 ,2 8例。所有病例随访 5年以上。结果 :3年生存率Ⅰ、Ⅱ、Ⅲ、Ⅳ组分别为 1 5 .6 %、2 1 .6 %、4 2 .5 %、39.3% ,其中Ⅲ、Ⅳ组与对照组间有显著性差异。 5年生存率各组分别为 9.4 %、1 6 .2 %、30 .0 %、2 5 .0 % ,其中Ⅲ组与对照组间有显著性差异。结果表明综合组优于单放组 ,尤以顺铂加放射治疗为佳 ,值得进一步探索应用。更多还原

【Abstract】 From Jan. 1985 to Feb. 1986, 180 patients with esophageal, carcinoma were entered into this study. All patients were inoperable or who refused operation. Because parts of the cases data were lost, the number of analysed cases was 137. All patients were followed for at least 5-year. Patients were randomly divided into four groups: A, control group (radiation alone with the dose of 55～65 Gy in 5～7 weeks) 32 patients. B, radiation plus ping yangmycin (10mg im, twice a week), 37 patients. C, radiation plus cisplatin (20mg, iv. twice a week) 40 patients.D, radiation plus both 28 patients. The 3-year survival rates were 15.6%, 21.6%, 42.5% and 39.3%, respectively. There were significantly differences between C and A or D and B groups, respectively (P<0.05). The 5-year survival rates were 9.4%, 16.2%, 30% and 25%, respectively. The difference was significant between group C and A (P<0.05). The results showed that radiation plus cisplatin was better than radiation alone.更多还原