【摘要】 采用放射免疫方法测定１７例人初乳、１８例人成熟乳、８例牛初乳及２０例牛成熟乳中胃动素浓度，同时测定了人乳中胃泌素浓度。结果：人初乳胃动素浓度为４１６．３４±１８３．９５ｎｇ／Ｌ人成熟乳为２７２．９１±１４８．７３ｎｇ／Ｌ二者比较，差异有显著性（Ｐ＜０．０２）；牛初乳中胃动素浓度为２２９．５１±６３．６８ｎｇ／Ｌ，牛成熟乳为３５．４６±１６．９４ｎｇ／Ｌ，二者比较，差异有非常显著性（Ｐ＜０．０１）；人初乳或成熟乳与牛初乳或成熟乳比较，胃动素浓度差异也有非常显著性（均为Ｐ＜０．０１）；人初乳中胃泌素浓度为１７．２０±１１．９８ｎｇ／Ｌ，高于人成熟乳的５．６２±２．３３ｎｇ／Ｌ（Ｐ＜０．０１）。提示：乳汁中含有一定数量的胃肠激素，尤以人初乳中浓度为高。早期母乳喂养可促进新生儿及婴儿胃肠组织的成熟和功能的建全。更多还原

【Abstract】 bjective To determine if motilin and gastrin are present in breast milk and to measure their con-centrations in human milk and cow milk.Methods The concentration of motilin was measured in 17 samples of human colostrum ’18 sam-ples of human mature milk,8 samples of cow colostrum and 20 samples of cow mature milk by radioim-munoassay. The concentration of gastrin in human milk was also determined by radioimmunoassay. Results Motilin concentration in human colostrum was the highest (416.34 ± 183. 95ng/L), be-ing higher than that in human mature milk (272.91±148.73ng/L),that in cow colostrum (229.51±63. 68ng/L)and that in cow mature milk ( 35.46 ± 1 6. 94ng/N. Evidently the difference in motilin concentration was very significant between human milk and cow milk.The gastrin concentration in hu-man colostrum was 17. 20 ± 11. 98ng/L,being higher than that in human mature milk(5.62 ± 2.33ng/L). Concl usions Human milk,especially human colostrum,contains high concentrations of motilin and gastrin;Breast feeding,especially early breast feeding,may promote the maturation of the develop-ing gut in neonates and infants.更多还原