【摘要】 报道５例罕见的食管基底细胞样鳞状细胞癌。其病理特点为瘤组织以基底细胞佯癌组织为主要成分，并伴有鳞状细胞分化、粉刺状坏死和癌巢内基质玻璃样变。免疫组化显示，基底细胞样癌成分对４种上皮性抗体（高分子量角蛋白Ｋｅｒａｔｉｎ、低分子量角蛋白１０．１１、ＣＥＡ、ＥＭＡ）呈阴性或弱阳性反应，而对Ａｃｔｉｎ及Ｓ－１００部分强阳性。提示此癌分化不良并有向肌上皮等多向分化倾向。临床上此癌高度恶性，首次手术的病例已有区域淋巴结和肺转移。随访４例均死亡，术后存活期平均１２．５个月。更多还原

【Abstract】 cases of basaloid-squamous carcinoma ( BSC)of Oesophagus were reported.Their pathological feautres were:1 The main component of the tumors were basaloid carciinoma cells.2.Concomitant squamous cell differentiation. 3.Comedo-like necrosis in the basaloid carcinoma component of the tu-mor.4.Hyaline degeneration within the stroma of the basaloid carcinoma nests(PAS + ).The im-munohistochemistry of keratin 10.11,CEA and EMA in the basaloid carcinoma component of BSC were negative or weak positive,while actin and S-100 were positive in some parts of the tumor sections.This suggested that the carcinoma component was pcorly differentiated and somewhat tended to differentiate toward myoepithelia or other directions.We therefore consider that the origin of BSC may be the primi-tive totipotential cell. BSCoccurred more frequently in elderly males,The biological behavior of BSC was highly malignant.Regional lymph nodes or distant organ metastasis were usually found at the first operation. The mean survival period after operation was very short,BSC was therefore considered to be aspecific clinicopatholoigcal entity.更多还原