【摘要】 用放射示踪术研究了肾显像剂^99mTc-PAHIDA摄入体内的代谢特性与临床诊断使用。观察表明,^99mTc-PAHIDA在体内呈优势定位于肾脏,而在其后依次为心脏、胃肠道、肝、脾、股四头肌、脂肪、睾丸和脑组织。尤其值得指出的是,当该肾显像剂的摄入量愈低时,则其在肾脏的选择性浓集程度就愈高。同时其与血浆蛋白的结合程度就愈低。^99mTc-PAHIDA可迅速经肾脏排出体外,而且由尿色层分析放射自显影观察得到一个放射峰,从而证明^99mTc-PAHIDA在体内是以原形经尿排除的。更多还原

【Abstract】 The metabolic peculiarities of renal radiotracer 99mTc-PAHIDA and diagnostic use were studied. The results of the radioactive tracing study showed that 99mTc-PAHIDA was distributed predominantly in kidney, and then in heart,gastrointestinal tract, liver, spleen, musculus quadriceps femoris, adipose tissue, testes and brain. It should be noted that when smaller dose of this agent was given, more 99mTc-PAHIDA was concentrated in kidney and, at the same time, the level of its binding to plasma protein was lower. The experimental results indicated that 99mTc-PAHIDA was rapidly excreted in urine. Autoradiochromatographic examination of the urine showed a single radioactive peak corresponding to the authentic 99mTc-PAHIDA, indicating that 99mTc-PAHIDA was excreted in the unchanged form.更多还原