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131I─抗胃癌单克隆抗体在胃癌病人体内的药代动力学研究

A Pharmacokinetic Study of131I-labelled Murine Anti-human Gastric Cancer Antibody Patiens with Gastric Cancer

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【作者】 刘宝国徐光炜董志伟张梅颖李振甫金懋林林宝和许小宝

【Author】 Liu Bao-Guo; Xu Guang-Wei; Dong Zhi-Wei et al (Beijing Institute for Cancer Research, Beijing)

【机构】 北京市肿瘤防治研究所

【摘要】 用碘标记抗胃癌单克隆抗体((131)I-3H(11))对14例胃癌患者进行放射免疫导向手术中的药代动力学研究。静脉给药组(IV)(n=7)和胃镜粘膜下给药组(Endo)(n=7)其动力学模型经微机拟合均为两室模型。T1/2β分别为22.65±1.38(IV)和21.02±2.18(Endo),统计学差异不显著。两种给药方式消除规律相似,IV组并不比Endo组清除快。

【Abstract】 The pharmacokinetics of radioiodinated murine anti-human gastric cancer antibody(MAb 3H(11))radioimmunoguided surgery in 14 patients with gastric cancer was evaluated with isotopic tracing. The microcomputer graphic portrayal conform to a two-compartment model for both intravenous administration (IV)(n=7)and submucous membrane injection at endoscopic Samples(Endo)(n=7).The difference of the elimination half-life between the IV group(22. 65±1. 38)and Endo group(21.02±2.18)was not significant(P>0.05). These results indicate that radioiodinated antibody administered via Endo is not cleared more rapidly than intravenous injection.

  • 【文献出处】 中国肿瘤临床 ,CHINESE JOURNAL OF CLINICAL ONCOLOGY , 编辑部邮箱 ,1995年05期
  • 【分类号】R735.2
  • 【被引频次】5
  • 【下载频次】40
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