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131I─抗胃癌单克隆抗体在胃癌病人体内的药代动力学研究
A Pharmacokinetic Study of131I-labelled Murine Anti-human Gastric Cancer Antibody Patiens with Gastric Cancer
【摘要】 用碘标记抗胃癌单克隆抗体((131)I-3H(11))对14例胃癌患者进行放射免疫导向手术中的药代动力学研究。静脉给药组(IV)(n=7)和胃镜粘膜下给药组(Endo)(n=7)其动力学模型经微机拟合均为两室模型。T1/2β分别为22.65±1.38(IV)和21.02±2.18(Endo),统计学差异不显著。两种给药方式消除规律相似,IV组并不比Endo组清除快。
【Abstract】 The pharmacokinetics of radioiodinated murine anti-human gastric cancer antibody(MAb 3H(11))radioimmunoguided surgery in 14 patients with gastric cancer was evaluated with isotopic tracing. The microcomputer graphic portrayal conform to a two-compartment model for both intravenous administration (IV)(n=7)and submucous membrane injection at endoscopic Samples(Endo)(n=7).The difference of the elimination half-life between the IV group(22. 65±1. 38)and Endo group(21.02±2.18)was not significant(P>0.05). These results indicate that radioiodinated antibody administered via Endo is not cleared more rapidly than intravenous injection.
【Key words】 Radioiodinate; Murine anti-human gastric cancer antibody; Elimination half-life; Pharmacokinetics;
- 【文献出处】 中国肿瘤临床 ,CHINESE JOURNAL OF CLINICAL ONCOLOGY , 编辑部邮箱 ,1995年05期
- 【分类号】R735.2
- 【被引频次】5
- 【下载频次】40